Holders Sevilla FC were the only away side to win their round of 16 first leg, though their two-goal victory was matched by FC Zenit, VfL Wolfsburg and SSC Napoli.
FC Zenit 2-0 Torino FC VfL Wolfsburg 3-1 FC Internazionale Milano Club Brugge KV 2-1 Beşiktaş JK FC Dnipro Dnipropetrovsk 1-0 AFC Ajax Everton FC 2-1 FC Dynamo Kyiv ACF Fiorentina 1-1 AS Roma Villarreal CF 1-3 Sevilla FC SSC Napoli 3-1 FC Dinamo Moskva
Perhaps the standout moment of the night came at El Madrigal, where Sevilla midfielder Vitolo set a new record forthe fastest ever UEFA Europa League goal, opening the scoring after just 13.21 seconds. It was also a good night for Belgium, with Axel Witsel on target for Zenit, Kevin De Bruyne scoring twice for VfL Wolfsburg and Club Brugge KV seeing off Beşiktaş JK.
The second legs take place next Thursday, 19 March. The draw for the quarter-finals will take place in Nyon the following day.